CBRI Seminar – Christine Wells – 22nd April 2016

UOM-Hallmark_CompBiol-CMYK-REVThe Stemformatics stem cell atlas and multi-omic collaboration resource

Christine Wells

Professor, University of Melbourne

Department of Anatomy and Neuroscience

Friday 22nd April, 2016

11am-12pm

ESJ King Theatre, Medical Building

Stemformatics is a web resource designed to facilitate collaborations between the stem cell and bioinformatics/biostatistics communities. It consists of a curated stem cell atlas of more than 800 stem cell datasets, compiling transcriptome, proteome and epigenome data from thousands of stem cell samples. The atlas provides stem cell researchers with fast and intuitive views of individual genes, pathways or exemplar public projects. The atlas also provides a library of high quality, highly curated datasets for the computational biology community interested in method development or integrative ‘omic analyses. I will describe our own research program in cross-platform transcriptome modelling of stem cell ‘signatures’, using sparse variable selection methods for stem cell classification.
Associated reading:
Stemformatics: visualisation and sharing of stem cell gene expression CA Wells,et al Stem cell research 10 (3), 387-395
YuGene: A simple approach to scale gene expression data derived from different platforms for integrated analyses KA Lê Cao, et al Genomics 103 (4), 239-251
Rohart F, et al  (2016) A molecular classification of human mesenchymal stromal cells. PeerJ 4:e1845https://doi.org/10.7717/peerj.1845

Enquiries: Andrew Siebel (asiebel@unimelb.edu.au)