The Systems Biology of the Insect: Insecticide Interface
Professor Phil Batterham
Friday 13th May
11:15am-12:15pm (NOTE: Later start)
ESJ King Theatre, Medical Building, The University of Melbourne
Exposure to sub-lethal doses of insecticides is of interest because of concerns about their impact on beneficial organisms (e.g. honeybees) and the potential for such doses to select for insecticide resistance in pests. In research sub-lethal doses offer significant benefit in allowing the insecticide:insect interaction to be examined in insects that are alive. We are using novel technologies that allow us to correlate in vivo insecticide metabolism with the impact of insecticides on the brain in insects exposed to two different neurotoxic insecticides, (imidacloprid and spinosad) that both target nicotinic acetylcholine receptors. Deploying these technologies in the model insect, Drosophila melanogaster (using RNAi screens, Genome Wide Association Studies and CRISPR gene knockouts) is allowing us to identify genes involved in processes including insecticide metabolism, transport and neurotransmission that underpin responses to these insecticides.
Enquiries: Andrew Siebel (firstname.lastname@example.org)