CBRI Seminar – Jonathan Keith – 17th June, 2016

UOM-Hallmark_CompBiol-CMYK-REVDetecting ncRNAs in the human genome using Bayesian multiple change-point models

Jonathan Keith (Monash University)

Friday 17th June, 2016


ESJ King Theatre, Medical Building, The University of Melbourne

Large numbers of currently unidentified functional ncRNAs, even whole classes of undiscovered elements, are likely to be encoded in the human and other genomes. In this talk I will discuss ~1000 putative new ncRNAs, most of which are located in the introns of transcription factors, that are conserved in the genomes of human, mouse and zebrafish. The methodology used to identify these elements involves Bayesian multiple change-point models used to segment alignments into classes with characteristic patterns of base composition, conservation level and mutational biases. These putative ncRNAs were detected as the result of joint work with Dr Robert Bryson-Richardson at Monash University.

Associate Professor Jonathan Keith was awarded a PhD in mineral processing by the University of Queensland in 2000, and was a postdoctoral fellow there and at Queensland University of Technology before moving to Monash University. He has worked in Bayesian methodology and applications since 2000 and has developed a trans‐dimensional generalisation of the Gibbs sampler and adaptive Markov chain Monte Carlo methods. His methods have been applied in comparative genomics to investigate the non‐protein‐coding fraction of eukaryotic genomes, and also in phylogenetics, in genetic linkage and association studies, and in modelling the spread of invasive pest species.

Enquiries: Andrew Siebel (asiebel@unimelb.edu.au)