The painting palettes of human ancestry
Dr Daniel Falush
Swansea University, UK
Monday 27th June
ESJ King Theatre, Medical Building, The University of Melbourne
A first step in many genomic analyses is to describe how individuals are related to each other. In this talk, I will describe how chromosome painting can be used to summarize relatedness and describe recent patterns of genetic drift and admixture. One of the most popular methods has been the STRUCTURE model (also implemented in the program ADMIXTURE). I will show that STRUCTURE barplots can be quite misleading but that a comparison with chromosome painting results can be used to provide a richer as well as more reliable description of recent demographic history.
Daniel Falush is a statistical geneticist who has worked on bacteria such as Helicobacter pylori, Campylobacter jejuni and humans and developed a wide variety of algorithms including the chromopainter/fineSTRUCTURE pipeline, ClonalFrame and MetaPalette. He has a somewhat itinerant job history which will involve moving to the University of Bath on 1st August and is playful with ands and commas.
Enquiries: Andrew Siebel (firstname.lastname@example.org)