Systems Genomics Approaches and Applications in Metabolic and Brain Diseases
Associate Professor Xia Yang
Department of Integrative Biology and Physiology, UCLA
Wednesday 30th November
ESJ King Theatre, Medical Building, The University of Melbourne
Technological advances in the past decade have enabled an outpour of multi-omics big data in biomedical research. Accompanying the data flood is the challenge of big data integration. Our research aims to design and utilize powerful systems genomics approaches that harmonize multi-omics data from human and model systems to dissect the molecular underpinnings of complex human diseases. In this talk, I will introduce i) systems genomics approaches and a versatile data integration tool (Mergeomics) we have developed to accommodate diverse omics data types from different species for network modeling of pathophysiological systems, and iii) the application of these methods in metabolic and brain disorders. These efforts have led to the elucidation of systems-level tissue-specific networks and critical regulators either specific to individual diseases or shared between diseases. The systems and network level insights will help guide the development of novel network-based medicine for common complex human diseases.
Dr. Xia Yang is an Associate Professor in the Department of Integrative Biology and Physiology and a faculty member of the Institute for Quantitative and Computational Biosciences at the University of California, Los Angeles (UCLA). She obtained her Ph.D. degree in Molecular Genetics with an emphasis on Bioinformatics in the Department of Biology of Georgia State University in 2003, followed by a postdoctoral training in mouse genetics, integrative genomics, and cardiometabolic diseases with Dr. A. Jake Lusis in the Departments of Human Genetics and Medicine at UCLA between 2003 and 2006. Subsequently, she worked as a Senior Research Scientist in the Department of Genetics at Rosetta Inpharmatics, a wholly owned subsidiary of Merck & Co. from 2006 to 2009 studying the molecular networks of cardiometabolic diseases using integrative genomics and network biology approaches. She then served as Director and Principal Scientist of Systems Biology at Sage Bionetworks from 2009-2011 before returning to UCLA as an Assistant Professor in the Department of Integrative Biology and Physiology in 2011. She became a tenured Associated Professor at UCLA in 2016. Dr. Yang’s research has been focused on developing and applying integrative genomics and systems biology approaches to understand gene networks perturbed by genetic and environmental risks of cardiometabolic diseases and comorbidities (https://yanglab.ibp.ucla.edu).
Enquiries: Andrew Siebel (firstname.lastname@example.org)